abstract：:Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. GH1, GH5, and GH30 g...

journal_title：Journal of lipid research

authors： Ben Bdira F,Artola M,Overkleeft HS,Ubbink M,Aerts JMFG

更新日期：2018-12-01 00:00:00

abstract：:In breast cancer, 17β-estradiol (E2) plays critical roles mainly by binding to its canonical receptor, estrogen receptor (ER) α66, and eliciting genomic effects. E2 also triggers rapid, nongenomic responses. E2 activates sphingosine kinase 1 (SphK1), increasing sphingosine-1-phosphate (S1P) that binds to its receptors...

journal_title：Journal of lipid research

authors： Maczis MA,Maceyka M,Waters MR,Newton J,Singh M,Rigsby MF,Turner TH,Alzubi MA,Harrell JC,Milstien S,Spiegel S

更新日期：2018-12-01 00:00:00

abstract：:The initial studies of the metabolism of arachidonic acid (AA) by the cytochrome P450 (P450) hemeproteins sought to: a) elucidate the roles for these enzymes in the metabolism of endogenous pools of the FA, b) identify the P450 isoforms involved in AA epoxidation and ω/ω-1 hydroxylation, and c) explore the biological ...

journal_title：Journal of lipid research

authors： Capdevila JH,Falck JR

更新日期：2018-11-01 00:00:00

abstract：:Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages of HIV disease progression. In this cross-sectional study, CE fr...

journal_title：Journal of lipid research

authors： Tort O,Escribà T,Egaña-Gorroño L,de Lazzari E,Cofan M,Fernandez E,Gatell JM,Martinez E,Garcia F,Arnedo M

更新日期：2018-11-01 00:00:00

abstract：:Ac-hE18A-NH2 is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141-150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH2 reduces plasma cholesterol in animal models and exhibits anti-inflammatory properties...

journal_title：Journal of lipid research

authors： Anantharamaiah GM,Garber DW,Goldberg D,Morrel E,Datta G,Palgunachari MN,Register TC,Appt SE,White CR

更新日期：2018-11-01 00:00:00

abstract：:Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived oxylipins with potential physiological relevance in inflammatory processes as well as in maintaining an intact skin barrier. Due to the high number of possible TriHOME isomers with only subtle differences in their physicochemical properties, the stereoc...

journal_title：Journal of lipid research

authors： Fuchs D,Hamberg M,Sköld CM,Wheelock ÅM,Wheelock CE

更新日期：2018-10-01 00:00:00

abstract：:After crossing floxed stearoyl-CoA desaturase-1 (Scd1fl/fl) mice with LDL receptor-null (ldlr-/-) mice, and then Villin Cre (VilCre) mice, enterocyte Scd1 expression in Scd1fl/fl/ldlr-/-/VilCre mice was reduced 70%. On Western diet (WD), Scd1fl/fl/ldlr-/- mice gained more weight than Scd1fl/fl/ldlr-/-/VilCre mice (P <...

journal_title：Journal of lipid research

authors： Mukherjee P,Hough G,Chattopadhyay A,Grijalva V,O'Connor EI,Meriwether D,Wagner A,Ntambi JM,Navab M,Reddy ST,Fogelman AM

更新日期：2018-10-01 00:00:00

abstract：:Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption consider...

journal_title：Journal of lipid research

authors： Cuerq C,Henin E,Restier L,Blond E,Drai J,Marçais C,Di Filippo M,Laveille C,Michalski MC,Poinsot P,Caussy C,Sassolas A,Moulin P,Reboul E,Charriere S,Levy E,Lachaux A,Peretti N

更新日期：2018-09-01 00:00:00

abstract：:The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

journal_title：Journal of lipid research

authors： White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

更新日期：2018-09-01 00:00:00

abstract：:Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate ...

journal_title：Journal of lipid research

authors： Liss KHH,Lutkewitte AJ,Pietka T,Finck BN,Franczyk M,Yoshino J,Klein S,Hall AM

更新日期：2018-09-01 00:00:00

abstract：:Adipogenic differentiation is a highly regulated process that is necessary for metabolic homeostasis and nutrient sensing. The expression of PPARγ and the subsequent activation of adipogenic genes is critical for the process. In this study, we identified lanthionine synthetase C-like protein 2 (LanCL2) as a positive r...

journal_title：Journal of lipid research

authors： Dutta D,Lai KY,Reyes-Ordoñez A,Chen J,van der Donk WA

更新日期：2018-08-01 00:00:00

abstract：:Dysregulation of nuclear envelope (NE) assembly results in various cancers; for example, renal and some lung carcinomas ensue due to NE malformation. The NE is a dynamic membrane compartment and its completion during mitosis is a highly regulated process, but the detailed mechanism still remains incompletely understoo...

journal_title：Journal of lipid research

authors： Chung GHC,Domart MC,Peddie C,Mantell J,Mclaverty K,Arabiotorre A,Hodgson L,Byrne RD,Verkade P,Arkill K,Collinson LM,Larijani B

更新日期：2018-08-01 00:00:00

abstract：:Lipidomics, the mass spectrometry-based comprehensive analysis of lipids, has attracted attention as an analytical approach to provide novel insight into lipid metabolism and to search for biomarkers. However, an ideal method for both comprehensive and quantitative analysis of lipids has not been fully developed. Here...

journal_title：Journal of lipid research

authors： Takeda H,Izumi Y,Takahashi M,Paxton T,Tamura S,Koike T,Yu Y,Kato N,Nagase K,Shiomi M,Bamba T

更新日期：2018-07-01 00:00:00

abstract：:Apicomplexan parasites are pathogens responsible for major human diseases such as toxoplasmosis caused by Toxoplasma gondii and malaria caused by Plasmodium spp. Throughout their intracellular division cycle, the parasites require vast and specific amounts of lipids to divide and survive. This demand for lipids relies...

journal_title：Journal of lipid research

authors： Dubois D,Fernandes S,Amiar S,Dass S,Katris NJ,Botté CY,Yamaryo-Botté Y

更新日期：2018-06-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is associated with a severe pro-inflammatory response; although decreased plasma cholesterol concentration has been linked to systemic inflammation, any association of phospholipid metabolic pathways with ARDS has not been characterized. Plasma phosphatidylcholine (PC), the m...

journal_title：Journal of lipid research

authors： Dushianthan A,Cusack R,Grocott MPW,Postle AD

更新日期：2018-06-01 00:00:00

abstract：:Ethanolamine phosphotransferase (EPT)1, also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids, such as diacyl-linked phosphatidylethanolamine (PE) and ether-linked plasmalogen [1-al...

journal_title：Journal of lipid research

authors： Horibata Y,Elpeleg O,Eran A,Hirabayashi Y,Savitzki D,Tal G,Mandel H,Sugimoto H

更新日期：2018-06-01 00:00:00

abstract：:Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and conventional lipids with carotid intima-media thickness (IMT) measured c...

journal_title：Journal of lipid research

authors： Basu A,Jenkins AJ,Stoner JA,Zhang Y,Klein RL,Lopes-Virella MF,Garvey WT,Schade DS,Wood J,Alaupovic P,Lyons TJ,Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Research Group.

更新日期：2018-05-01 00:00:00

abstract：:In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity declin...

journal_title：Journal of lipid research

authors： Kotzbeck P,Giordano A,Mondini E,Murano I,Severi I,Venema W,Cecchini MP,Kershaw EE,Barbatelli G,Haemmerle G,Zechner R,Cinti S

更新日期：2018-05-01 00:00:00

abstract：:Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J mice through enhanced cholesterol conversion to b...

journal_title：Journal of lipid research

authors： Lee JM,Ong JR,Vergnes L,de Aguiar Vallim TQ,Nolan J,Cantor RM,Walters JRF,Reue K

更新日期：2018-03-01 00:00:00

abstract：:The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to stu...

journal_title：Journal of lipid research

authors： Hu A,Zhao XT,Tu H,Xiao T,Fu T,Wang Y,Liu Y,Shi XJ,Luo J,Song BL

更新日期：2018-03-01 00:00:00

abstract：:Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular m...

journal_title：Journal of lipid research

authors： Padmanabha Das KM,Wechselberger L,Liziczai M,De la Rosa Rodriguez M,Grabner GF,Heier C,Viertlmayr R,Radler C,Lichtenegger J,Zimmermann R,Borst JW,Zechner R,Kersten S,Oberer M

更新日期：2018-03-01 00:00:00

abstract：:The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2α) enzyme directs a complex "eicosanoid storm" that accompanies the tissue response to injury. cPLA2α and its downstream eicosanoid mediators are also implicated in the pathogenesis of fibrosis in many organs, including the kidney. We aimed to determine ...

journal_title：Journal of lipid research

authors： Montford JR,Lehman AMB,Bauer CD,Klawitter J,Klawitter J,Poczobutt JM,Scobey M,Weiser-Evans M,Nemenoff RA,Furgeson SB

更新日期：2018-02-01 00:00:00

abstract：:Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here, we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT. With this technique, we were able to detect 3KDS at a level comparable to that of...

journal_title：Journal of lipid research

authors： Ren J,Snider J,Airola MV,Zhong A,Rana NA,Obeid LM,Hannun YA

更新日期：2018-01-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:Delta 6 desaturase (FADS2) is a critical bifunctional enzyme required for PUFA biosynthesis. In some organisms, FADS2s have high substrate specificity, whereas in others, they have high catalytic activity. Previously, we analyzed the molecular mechanisms underlying high FADS2 substrate specificity; in this study, we a...

journal_title：Journal of lipid research

authors： Shi 史海粟 H,Wu 乌日娜 R,Zheng 郑艳 Y,Yue 岳喜庆 X

更新日期：2018-01-01 00:00:00

abstract：:Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2-/- mice contain reduced content of LDs and accumulate less ...

journal_title：Journal of lipid research

authors： Feng YZ,Lund J,Li Y,Knabenes IK,Bakke SS,Kase ET,Lee YK,Kimmel AR,Thoresen GH,Rustan AC,Dalen KT

更新日期：2017-11-01 00:00:00

abstract：:Familial dysbetalipoproteinemia (FD) is a genetic disorder associated with impaired postprandial lipid clearance. The effect of adding bezafibrate to standard lipid-lowering therapy on postprandial and fasting lipid levels in patients with FD is unknown. In this randomized placebo-controlled double-blind crossover tri...

journal_title：Journal of lipid research

authors： Koopal C,Marais AD,Westerink J,van der Graaf Y,Visseren FLJ

更新日期：2017-11-01 00:00:00

abstract：:Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese patients and mice is cl...

journal_title：Journal of lipid research

authors： Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J

更新日期：2017-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by an extensive accumulation of amyloid-β (Aβ) peptide, which triggers a set of deleterious processes, including synaptic dysfunction, inflammation, and neuronal injury, leading to neuronal loss and cognitive impairment. A large body of evidence supports that nuclear receptor ...

journal_title：Journal of lipid research

authors： Moutinho M,Landreth GE

更新日期：2017-10-01 00:00:00

abstract：:Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacyl-glycerol (TAG). We investigated the effect of Agpat4 gene ablation on white adipose tissue (WAT) after finding consistent expression across depots. Epidi...

journal_title：Journal of lipid research

authors： Mardian EB,Bradley RM,Aristizabal Henao JJ,Marvyn PM,Moes KA,Bombardier E,Tupling AR,Stark KD,Duncan RE

更新日期：2017-10-01 00:00:00

abstract：:SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2-/- ) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of Vil-BP2-/- mice had reduced expression of genes required for sterol synt...

journal_title：Journal of lipid research

authors： Rong S,McDonald JG,Engelking LJ

更新日期：2017-10-01 00:00:00

abstract：:HDL plays crucial roles at multiple stages of the pathogenesis of atherosclerosis. AMP-activated protein kinase (AMPK) is a therapeutic candidate for the treatment of cardiovascular disease. However, the effect of AMPK activation on HDL functionality has not been established in vivo. We assessed the effects of pharmac...

journal_title：Journal of lipid research

authors： Ma A,Wang J,Yang L,An Y,Zhu H

更新日期：2017-08-01 00:00:00

abstract：:Small dense LDL (sdLDL) has been reported to be more atherogenic than large buoyant LDL (lbLDL). We examined the metabolism and protein composition of sdLDL and lbLDL in six subjects with combined hyperlipidemia on placebo and rosuvastatin 40 mg/day. ApoB-100 kinetics in triglyceride-rich lipoproteins (TRLs), lbLDL (d...

journal_title：Journal of lipid research

authors： Thongtang N,Diffenderfer MR,Ooi EMM,Barrett PHR,Turner SM,Le NA,Brown WV,Schaefer EJ

更新日期：2017-07-01 00:00:00

abstract：:Previous studies have shown that reduced levels of the adipocyte fatty acid binding protein (FABP)4 (AFABP/aP2), result in metabolic improvement including potentiated insulin sensitivity and attenuated atherosclerosis. Mechanistically, pharmacologic or genetic inhibition of FABP4 in macrophages upregulates UCP2, atten...

journal_title：Journal of lipid research

authors： Hertzel AV,Xu H,Downey M,Kvalheim N,Bernlohr DA

更新日期：2017-07-01 00:00:00

abstract：:In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid in humans and rodents is largely unknown. Here, w...

journal_title：Journal of lipid research

authors： Watanabe M,Fukiya S,Yokota A

更新日期：2017-06-01 00:00:00

abstract：:Triglyceride (TG) concentration is used as a marker of cardiometabolic risk. However, diurnal and possibly weekday variation exists in TG concentrations. The objective of this work was to investigate weekday variation in TG concentrations among 1.8 million blood samples drawn between 2008 and 2015 from patients in the...

journal_title：Journal of lipid research

authors： Jaskolowski J,Ritz C,Sjödin A,Astrup A,Szecsi PB,Stender S,Hjorth MF

更新日期：2017-06-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is a treatable neurodegenerative metabolic disorder of bile acid synthesis in which symptoms can be prevented if treatment with chenodeoxycholic acid supplementation is initiated early in life, making CTX an excellent candidate for newborn screening. We developed a new dried blood ...

journal_title：Journal of lipid research

authors： Vaz FM,Bootsma AH,Kulik W,Verrips A,Wevers RA,Schielen PC,DeBarber AE,Huidekoper HH

更新日期：2017-05-01 00:00:00

abstract：:Changes in chromatin structure regulate gene expression and genome maintenance. Molecules that bind to the nucleosome, the complex of DNA and histone proteins, are key modulators of chromatin structure. Previous work indicated that cholesterol, a ubiquitous cellular lipid, may bind to chromatin in vivo, suggesting a p...

journal_title：Journal of lipid research

authors： Silva ITG,Fernandes V,Souza C,Treptow W,Santos GM

更新日期：2017-05-01 00:00:00

abstract：:In recent years the short-chain fatty acid, 4-phenylbutyrate (PB), has emerged as a promising drug for various clinical conditions. In fact, PB has been Food and Drug Administration-approved for urea cycle disorders since 1996. PB is more potent and less toxic than its metabolite, phenylacetate (PA), and is not just a...

journal_title：Journal of lipid research

authors： Palir N,Ruiter JPN,Wanders RJA,Houtkooper RH

更新日期：2017-05-01 00:00:00

abstract：:The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Mycobacterium tuberculosis (Mtb), can induce this foam phenotype possibly as a way to p...

journal_title：Journal of lipid research

authors： Vermeulen I,Baird M,Al-Dulayymi J,Smet M,Verschoor J,Grooten J

更新日期：2017-04-01 00:00:00